Rats are unable to discriminate quinine from diverse bitter stimuli
نویسندگان
چکیده
منابع مشابه
Rats fail to discriminate quinine from denatonium: implications for the neural coding of bitter-tasting compounds.
Recent molecular findings indicate that many different G-protein-coupled taste receptors that bind with "bitter-tasting" ligands are coexpressed in single taste receptor cells in taste buds, leading to the prediction that mammals can respond behaviorally to structurally diverse "bitter" tastants but cannot discriminate among them. However, recent in situ calcium-imaging findings imply that rat ...
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Bitter taste is one of the five basic taste sensations which is mediated by 25 bitter taste receptors (T2Rs) in humans. The mechanism of bitter taste signal transduction is not yet elucidated. The cellular processes underlying T2R desensitization including receptor internalization, trafficking and degradation are yet to be studied. Here, using a combination of molecular and pharmacological tech...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2019
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00213.2019